| Sustainable funding to expand Australia's bowel cancer research capacity 
Bowel cancer is Australia's second deadliest cancer and has the second highest disease burden of any cancer in Australia.

Burden of disease measures the impact of living with illness and injury or dying prematurely.

However, bowel cancer received around 46 percent less research funding from the National Health and Medical Research Council (NHMRC) compared to breast cancer (2017: $12.2 million v $22.8 million); and receives no government funding to support dedicated Bowel Care Nurse Specialists, compared around $80 million for Breast Care Nurse Specialists and $30 million for Prostate Cancer Nurse Specialists.
NMRHC research funding v burden disease YLL

To help address this research funding inequity, Bowel Cancer Australia established the Bowel Cancer Research Foundation Australia.
An objective of the Foundation is to support and sustainably fund research into the causes, prevention and treatment of bowel cancer to benefit us all in the future. While Bowel Cancer Australia is here today supporting, informing and caring for people affected by the disease.

Through the Foundation, Bowel Cancer Australia has made a significant investment in the Lawrence Penn Chair of Bowel Cancer Research, dedicated to leading edge bowel cancer discoveries that aim to have an everlasting impact on Australia's health future.

The establishment of the Lawrence Penn Chair, in collaboration with the University of Sydney and the Kolling Institute, strengthens our collective pursuit of a bowel cancer cure.

Other major bowel cancer projects funded to date, include the ASCOLT Clinical Trial; ICHOM Colorectal Cancer Standard Set; community awareness and understanding; patient lived-experience; and demographic research;

To date, Bowel Cancer Australia, collaboratively with funding partners, has funded $11.6 million in bowel cancer research projects.

You can make a lasting contribution to bowel cancer research through a donation or a bequest (a gift made in your Will) to Bowel Cancer Australia or by calling us on 1800 555 494.
| Researching improved follow-up colonoscopy surveillance timings
Profiling of 60 bowel adenoma polyps will be used to better define optimal colonoscopic surveillance intervals, thanks to a new research grant to the Lawrence Penn Chair of Bowel Cancer Research from the Medical Research Future Fund (Sydney Health Partners).
Professor Mark Molloy, and his collaborators including Professor Alexander Engel from Royal North Shore Hospital will use molecular analysis of bowel polyps to investigate disease risk, seeking to find a signature of transformation risk which could potentially be used to optimise colonoscopy surveillance intervals.
"The research grant provided by the Medical Research Future Fund is exciting as it allows us to trial a pathway for molecular testing of bowel polyps and see if this information can tell us more about a given patient's bowel cancer risk,” said Professor Mark Molloy.
“It may offer an opportunity for more personalised prognosis as we will consider genetic, proteomic and microbiome features of these precancerous growths, which are not currently part of routine pathology testing," he added.
Researchers will use the local health district colonoscopy screening clinic to collect and analyse up to 60 polyps of varying risk levels.

"We will also explore if this molecular information may be useful for guiding follow-up colonoscopy surveillance timing as this would help improve scheduling and costs," Professor Molloy said.

Metastasise Lymph Nodes

| Researching why some early stage bowel tumours metastasise to lymph nodes

Funding from the Colorectal Surgical Society ANZ Foundation will support new research to improve our understanding of why some early stage bowel tumours metastasise to lymph nodes.

“This is important because patients with lymph node disease have worse prognosis and face more intense treatment than patients whose cancer remains within the bowel wall,” said Lawrence Penn Chair of Bowel Cancer Research Professor Mark Molloy.

The $60,000 research grant awarded to the Chair will enable molecular analysis to refine risk of dissemination in early stage tumours and transformation potential of some bowel polyps.

“Patients with Stage I bowel cancer have a greater than 98% 5-year rate of survival which falls to around 70% when the tumour has metastasized to lymph nodes,” Professor Molloy said.

“We need to better understand this process to develop medical interventions and stop the tumour disseminating elsewhere," he added.

The project will generate preliminary data using genomic sequencing of early stage tumours and malignant bowel polyps. Professor Molloy and his team aim to link these mutations with those early tumours which spread to lymph nodes, providing a biomarker of risk which may inform surgical pathways.

Dr Pascal Steffen

| Dr Pascal Steffen awarded Early Career Fellowship

A new grant secured by the Lawrence Penn Chair of Bowel Cancer Research laboratory from the Cancer Institute NSW will enable further investigation into the prognostic contribution of immune cell infiltration in rectal cancer.

The $600,000 grant will provide a three-year fellowship salary for Dr Pascal Steffen and help to cover some research costs for him to apply proteomic techniques to investigate the role of immune cells in rectal cancer.

Approximately 5,000 Australian men and women are diagnosed with rectal cancer each year. The aim of Dr Steffen’s CINSW fellowship is to understand the involvement of immune cell infiltration in rectal cancer, how this impacts tumour biology and how it affects patient outcomes.

To conduct the study over the next three years, Dr Steffen will apply his knowledge of protein mass spectrometry with access to the large archival rectal cancer tissue database at Royal North Shore Hospital. He will map the proteome (proteins found in the cancer) of these rectal cancers to understand their biology and how this links to patient prognosis, and work to resolve the complex immune cell architecture of these cancers by using a new technique of imaging mass cytometry.

The outcome of this research will lead to new prognostic biomarker panels, provide a better understanding of immune cells in rectal cancers and pave the way for new treatments.

“I am very excited to receive the CINSW fellowship as it will allow me to apply my expertise in proteomics to the cause of advancing the understanding of the role of immune cells in rectal cancer and furthering the research of new ways to combat this disease. This fellowship will also grant me the opportunity to broaden my knowledge especially in the field of immunology and imaging techniques,” said Dr Steffen.

Dr Pascal Steffen will conduct his fellowship in the Bowel Cancer and Biomarker Laboratory at The Kolling Institute, Royal North Shore Hospital in Sydney under the supervision of Professor Mark Molloy, Lawrence Penn Chair of Bowel Cancer Research, The University of Sydney.

“One of the key objectives for the Chair of Bowel Cancer Research is to increase research capacity and foster researcher development. I am delighted that the CINSW is supporting our vision through the award of this prestigious fellowship to Pascal. His research will reveal important new understandings in rectal cancer which is an essential step towards improving the outcomes for people with this disease,” Professor Molloy said.

Dr Pascal Steffen is a post-doctoral research associate (early career research fellow) and the newest member of the team working with the Lawrence Penn Chair of Bowel Cancer Research, Professor Mark Molloy.



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