A landmark global collaboration

In 2025, Bowel Cancer Australia joined 71 experts and advocates from 18 countries at the first-ever Global Think Tank on Early-Onset Colorectal (Bowel) Cancer (EOCRC), hosted in Barcelona.

Together, this unprecedented gathering explored why bowel cancer rates are rising among younger people and outlined the urgent steps needed to address this alarming trend.

The official 2025 Summary Report captures the outcomes of this historic event, providing fresh insights into the causes, risks, and priorities for action over the next two years.

Eight standing banners featuring diverse individuals with text in various languages, set in a conference room.

“Society expects us to ‘move on’ like nothing happened. But in reality, everything changed. The truth is you don’t move on. You move forward with it. With constant fear of recurrence, the changes, the challenges, and the side effects. These aren’t just moments; they are permanent shifts.”


~ Mia Ogalla Toledo, diagnosed at age 25.

What the report reveals

The 2025 Summary Report highlights the most pressing concerns and commitments identified at the Global Think Tank, including:

  • Rising rates of early-onset bowel cancer across multiple countries, even as overall bowel cancer rates decline.
  • Survey results from 500 patients in 21 countries, revealing the life-changing impact of early-onset bowel cancer on work, study, and family.
  • Only 15 per cent knew before diagnosis that bowel cancer could happen before 50.
  • Consistent evidence that young people are being diagnosed later and with a more aggressive disease.
  • Agreement among experts that awareness and education must be prioritised to improve early detection.

To address these, five global workgroups were established, focusing on research, data, biobanking, advocacy, and awareness to drive progress over the next two years.

Their findings confirm early-onset bowel cancer is a true global health crisis requiring urgent and united action.

Cover of a report titled "Early Onset Colorectal Cancer: A Global Call to Action," with logos and a blue background.

A global call to action

✅ Global early-onset bowel cancer data and patient insights
✅ Survey findings from 21 countries
✅ Top risk factors and research priorities
✅ Action plans from five global workgroups
✅ A call for collaboration and shared innovation

What we know so far

Experts identified several risk factors requiring urgent research, from lifestyle exposures to biological and genetic drivers. Including:

  • Obesity, poor nutrition, and high intake of processed foods
  • Disrupted circadian rhythms linked to shift work and poor sleep
  • Alcohol, smoking, and lack of physical activity
  • Colibactin mutations in the APC gene
  • Epithelium and microbiome changes
  • Potential genetic predispositions and familial syndromes
  • Geographic heterogeneity in incident rates
  • Young-onset metabolic syndrome and diabetes mellitus

The report also calls for unified research, improved data collection, and global awareness campaigns to accelerate outcomes for younger patients.

By pushing beyond what we already know, researchers aim to uncover why this disease is striking earlier and how best to prevent and treat it.

We have work to do

The Global Early-Onset Colorectal (Bowel) Cancer Think Tank marked the beginning of a powerful global effort to understand and address early-onset bowel cancer.

But progress depends on collaboration across borders, disciplines, and communities.

By downloading the report, you’ll gain access to the latest global data, patient insights, and the roadmap for the next phase of research advocacy.

A diverse group of people wearing blue hats poses together in front of a banner that reads "WE HAVE WORK TO DO."