Vectibix

Panitumumab
About Bowel Cancer Targeted-Therapies-Vectibix-770
 
At what stage is this treatment used?
 
  • Panitumumab is used as a first or second-line treatment option for patients with epidermal growth factor receptor (EGFR)-expressing, RAS wild-type advanced (metastatic) colorectal cancer in combination with chemotherapy.  Panitumumab can also be given as a single agent in patients who have failed or are intolerant to oxaliplatin-based therapy and irinotecan-based therapy.
  • Before you are prescribed panitumumab, your doctor will test your cancer cells to see if they contain either the normal (wild-type) or mutant forms of genes called RAS.  Panitumumab is used to treat patients who express normal (wild-type) RAS genes. 
 
Is this drug available via the Pharmaceutical Benefits Scheme (PBS) as a subsidised treatment?

  • Panitumumab is PBS-subsidised as monotherapy or in combination with an irinotecan based therapy, of a patient with a WHO performance status of 2 or less and with RAS wild type advanced (metastatic) colorectal cancer after failure to respond to first-line chemotherapy (i.e. panitumumab is currently PBS-subsidised as a second-line treatment option only).  The treatment must be the sole PBS-subsidised anti-EGFR antibody therapy for this condition.  

    Patients who have progressive disease on cetuximab are not eligible to receive PBS-subsidised panitumumab.  Patients who have developed intolerance to cetuximab of a severity necessitating permanent treatment withdrawal are eligible to receive PBS-subsidised panitumumab.
  • Panitumumab is also listed as a continuing PBS-subsidised treatment, as monotherapy or in combination with an irinotecan based therapy, of a patient with RAS wild-type advanced (metastatic) colorectal cancer who has previously been issued with an authority prescription for panitumumab and who does not have progressive disease.  The treatment must be the sole PBS-subsidised anti-EGFR antibody therapy for this condition.  

    Patients who have progressive disease on cetuximab are not eligible to receive PBS-subsidised panitumumab.  Patients who have developed intolerance to cetuximab of a severity necessitating permanent treatment withdrawal are eligible to receive PBS-subsidised panitumumab.  

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